共有50个其中有15个是秘密成就
 | Mission Impossible | 50  |
| Complete the game on Zealot setting |  | |
 | Romper Stomper | 25 |
| Stomp 10 Containers | | |
 | Vacuum Cleaner | 30 |
| Decompress 20 Necromorphs without getting sucked out yourself | | |
 | Made Us Whole | 10 |
| Complete the game on any difficulty setting | | |
 | Frozen in Time | 10 |
| Kill 50 Necromorphs while they are in Stasis (single player only) | | |
 | First Aid | 10 |
| Use Quick Heal ten times (single player only) | | |
 | Epic Dismemberment | 50 |
| Dismember 2,500 Necromorph Limbs (single player only) | | |
 | ...And Stay Down | 10 |
| Kill 25 crawling enemies with Stomp (single player only) | | |
 | Think Fast | 15 |
| Kill 30 Necromorphs with Kinesis objects | | |
 | The Nanny | 10 |
| Kill 30 Crawlers without detonating them | | |
 | C-Section | 10 |
| Knock down an enemy with Contact Beam Alt-Fire then kill it with Primary Fire before it stands up | | |
 | Going for Distance | 20 |
| Impale an enemy and make him fly through the air for 17 meters - it must stick to the surface | | |
 | Taste of your own Medicine | 20 |
| TK Impale a live Slasher to a surface using a Slashers arm - it must stick to the surface | | |
 | Its a Trap! | 20 |
| Kill 20 enemies with Detonator Mines in a deployed state | | |
 | Necro Flambé | 10 |
| Kill 50 enemies using the Flamethrower | | |
 | Peek a Boo! | 20 |
| Kill a Stalker with the Seeker Rifle while in Zoom Mode | | |
 | Brute Juke | 10 |
| Kill a Brute without taking damage | | |
 | Shoot the Limbs! | 10 |
| Dismember 25 Necromorph Limbs (single player only) | | |
 | Bouncing Betty | 10 |
| Kill a Cyst by catching its Mine and throwing it back | | |
 | Skewered in Space | 15 |
| Impale an enemy into a Decompression Window to cause it to blow out | | |
 | Hard to the Core | 50 |
| Complete the game on Hard Core setting | | |
 | Clean Cut | 10 |
| Sever all three tentacles of a Lurker with one Line Gun Primary Fire shot (single player only) | | |
 | Lawnmower Man | 10 |
| Kill 4 enemies with the same Ripper blade | | |
 | Fully Loaded | 50 |
| Simultaneously have four completely upgraded weapons | | |
 | The Sampler Platter | 20 |
| Kill a Necromorph with every Weapon in the game (single player only). | | |
 | Lightspeed de Milo | 10 |
| Dismember the Lightspeed Boy Statue | | |
 | Looking good | 10 |
| Purchase the Advanced Suit | | |
 | Fully Outfitted | 30 |
| Upgrade your RIG and Stasis completely | | |
 | Picking favorites | 30 |
| Upgrade 1 Weapon completely | | |
 | The Engineer | 10 |
| Collect 10 Schematics | | |
 | My Boom Stick | 20 |
| Kill 6 enemies at once with Line Guns Alt-Fire (single player only) | | |
 | Shock Therapy | 10 |
| Impale an enemy with the Javelin Gun and use its Alt-Fire to shock 3 others (single player only) | | |
 | Collect Peng | 20 |
| Find the Peng treasure |  (1) | |
 | The Librarian | 10 |
| Collect 100 logs | | |
| The Electrician | 10 |
| Collect 10 Semiconductors | |
